This is Chile's most productive and internationally known wine region, due predominately to its proximity to the national capital Santiago. It is located directly across the Andes from one of Argentina's wine regions: Mendoza Province. Within the Central Valley there are four wine growing region subregions: the Maipo Valley, the Rapel Valley, the Curicó Valley and the Maule Valley.
- The Maipo Valley is the most widely cultivated valley and is known for Cabernet Sauvignon.
- The Rapel wine region in the Colchagua Province is known for its Carmenere and Cabernet.
- Curicó has both red and white wine varieties planted but is most widely known for its Chardonnay.
- The Maule Valley has reatained large plantings of the local País although gradually it is being replaced with other red wine varieties.